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  • events, seminars

    May 12, 2023 – Jean-François Perrier (University of Copenhagen, Denmark) – Understanding the cellular mechanisms responsible for neurodevelopmental encephalopathies – the example of STXBP1 encephalopathies

    De novo mutations in Stxbp1 are among the most prevalent causes of neurodevelopmental disorders, and lead to haploinsufficiency, cortical hyperexcitability, epilepsy and other symptoms. Given that Munc18-1, the protein encoded by …  Continue reading

    events, seminars

    March 3, 2023 – Francesco BATTAGLIA (Radbound University, The Netherlands) – Hippocampal gamma oscillations mediating cortico-hippocampal oscillations and shaping hippocampal temporal code.

    Theta sequences and phase precession shape hippocampal activity and are considered key underpinnings of memory formation. Theta sequences are sweeps of spikes from multiple cells, tracing trajectories from past to future. Phase precession is the correlation between theta firing phase…  Continue reading

    events, seminars

    February 10, 2023 – Mohamed JABER (Université de Poitiers, France) – Genetic and environmental animal models of autism reproduce the spectrum of the disease

    Genetic and environmental factors increase autism spectrum disorder (ASD) incidence and this has led to the generation of corresponding animal models, with some showing strong construct and face validity. In this line, we have recently published a series of several studies on ASD environmental…  Continue reading

    events, seminars

    February 3, 2023 – Jenny GUNERSEY (University of Melbourne, Australia) – Excitatory synapse regulators and their potential as therapeutic targets in chronic conditions

    In this presentation, I will describe our recent work on a family of proteins with important roles in excitatory synapse development and maintenance. These proteins have been identified as substrates of the enzyme BACE1, a potential therapeutic target in Alzheimer’s…  Continue reading

    events, INC Meetings

    Friday 13th Awards

    The Friday the 13th was quite a success. Fourty PhD students and postdocs presented oral communications, posters and videos on their research and discuss them together at length before everyone shared the Kings’ Cake. At day’s end, the Jury of…  Continue reading

    events, INC Meetings

    Friday the 13th at INC!

    Discover the research topics of the INC teams on Friday the 13th of January at 2 pm at the headquarters of Paris Cité University, 12 rue de l’Ecole de Médecine. More than 40 PhD students and postdocs will present their…  Continue reading

    events, seminars

    Novembre 25, 2022 – Hélène Puccio (Institut NeuroMyoGene, Université Claude Bernard, Lyon and Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg) – Disruption of the CoQ10 biosynthetic Complex Q causes mitochondrial dysfunction and Ca2+ imbalance in Purkinje neurons in COQ8A-ataxia

    COQ8A-Ataxia is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The encoded mitochondrial protein is involved in the regulation of Coenzyme Q10 biosynthesis. Previous studies on the constitutive Coq8a-/- mice indicated specific alterations of cerebellar…  Continue reading

    events, seminars

    December 2, 2022 – Gabriel Lepousez (Perception and Memory Laboratory, Pasteur Institute) – How brain circuits sense and integrate peripheral immune signals

    Upon infection, bacterial compounds, and the pro-inflammatory cytokines they elicit, induce a complex response coordinated by the brain and known as “sickness behavior”. This response induces stereotyped behavioral changes (reduced locomotion and food intake, social avoidance), metabolic adjustments (fever, glycemia),…  Continue reading

    events, seminars

    9 Décembre 2022 – Jean-Michel Perrin (Institute of Biology Paris-Seine) – Reconstructing rodent and human neuronal networks to model neurodegenerative syndromes

    Human brain is a complex organ composed of several hundred billions of cells and even more numerous interconnected cellular interactions. There is a high demand for experimental models to study these interactions in various contexts, ranging from cognitive sciences…  Continue reading