events, seminars
November 3rd, 2023 – Jean-François Brunet (IBENS – ENS)- Genetic architecture of the autonomic nervous system
A general structure for the autonomic nervous system, divided into sympathetic and parasympathetic arms, was codified by John Newport Langley at the beginning of the XXth century. We propose a revision of this scheme based on neuron types. The “sacral… Continue reading
events, seminars
July 7th, 2023 – Mariano Soiza-Reilly (Institute of Physiology, Molecular Biology and Neurosciences – University of Buenos Aires – CONICET)- Synaptic refinement of afferents to raphe 5-HT neurons: Implications for psychiatric disorders
Psychiatric disorders including depression, anxiety and stress vulnerability represent main disabling conditions for individual’s life. Recent studies suggest that many aspects of these pathologies could have an early origin during childhood. Our goal is to investigate how maladaptive neurodevelopmental mechanisms… Continue reading
events, seminars
May 15, 2023 – Kishore Kuchibhotla (Johns Hopkins University, Baltimore, USA)- Insights and strategies during sensorimotor learning
Large-scale neural recordings provide an opportunity to better understand how the brain implements critical behavioral computations related to goal-directed learning. In this seminar, I will argue that re-visiting our understanding of the shape of the learning curve and… Continue reading
events, seminars
May 12, 2023 – Jean-François Perrier (University of Copenhagen, Denmark) – Understanding the cellular mechanisms responsible for neurodevelopmental encephalopathies – the example of STXBP1 encephalopathies
De novo mutations in Stxbp1 are among the most prevalent causes of neurodevelopmental disorders, and lead to haploinsufficiency, cortical hyperexcitability, epilepsy and other symptoms. Given that Munc18-1, the protein encoded by … Continue reading
events, seminars
March 3, 2023 – Francesco BATTAGLIA (Radbound University, The Netherlands) – Hippocampal gamma oscillations mediating cortico-hippocampal oscillations and shaping hippocampal temporal code.
Theta sequences and phase precession shape hippocampal activity and are considered key underpinnings of memory formation. Theta sequences are sweeps of spikes from multiple cells, tracing trajectories from past to future. Phase precession is the correlation between theta firing phase… Continue reading
events, seminars
February 10, 2023 – Mohamed JABER (Université de Poitiers, France) – Genetic and environmental animal models of autism reproduce the spectrum of the disease
Genetic and environmental factors increase autism spectrum disorder (ASD) incidence and this has led to the generation of corresponding animal models, with some showing strong construct and face validity.
In this line, we have recently published a series of several studies on ASD environmental… Continue reading
events, seminars
February 3, 2023 – Jenny GUNERSEY (University of Melbourne, Australia) – Excitatory synapse regulators and their potential as therapeutic targets in chronic conditions
In this presentation, I will describe our recent work on a family of proteins with important roles in excitatory synapse development and maintenance. These proteins have been identified as substrates of the enzyme BACE1, a potential therapeutic target in Alzheimer’s… Continue reading
events, INC Meetings
Friday 13th Awards
The Friday the 13th was quite a success. Fourty PhD students and postdocs presented oral communications, posters and videos on their research and discuss them together at length before everyone shared the Kings’ Cake.
At day’s end, the Jury of… Continue reading
events, INC Meetings
Friday the 13th at INC!
Discover the research topics of the INC teams on Friday the 13th of January at 2 pm at the headquarters of Paris Cité University, 12 rue de l’Ecole de Médecine.
More than 40 PhD students and postdocs will present their… Continue reading
events, seminars
Novembre 25, 2022 – Hélène Puccio (Institut NeuroMyoGene, Université Claude Bernard, Lyon and Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg) – Disruption of the CoQ10 biosynthetic Complex Q causes mitochondrial dysfunction and Ca2+ imbalance in Purkinje neurons in COQ8A-ataxia
COQ8A-Ataxia is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The encoded mitochondrial protein is involved in the regulation of Coenzyme Q10 biosynthesis. Previous studies on the constitutive Coq8a-/- mice indicated specific alterations of cerebellar… Continue reading