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  • Neuroscience Seminar Series

    Vendredi, 27 septembre 2019, 11:30, R229 (2e étage), Centre Universitaire des Saints Pères, 45 rue des Saints Pères, 75006 Paris

    Laura M. Bohn, Professor of Molecular Medicine and Neuroscience, The Scripps Research Institute in Jupiter, FL, USA
    Title: Harnessing opioid receptor signaling to improve
    therapeutic potential


    When drugs bind to receptors, they coordinate a series of signaling events that lead to
    physiological responses. Opioid receptors are G protein-coupled receptors (GPCRs);
    in addition to coupling to G proteins, they can be regulated by many different cellular
    proteins. The interactions between receptors and their signaling partners can vary
    between neuronal populations and tissues throughout the body; therefore there may
    be an opportunity to maintain efficacy in pain pathways while avoiding other side
    effects associated with opioid pain management. We are developing compounds
    that selectively engage certain signaling pathways over others to directly test if we
    can improve mu opioid receptor (MOR)- mediated pain relief while avoiding certain
    side effects, such as opioid overdose. Studies will also be presented comparing these
    compounds to conventional opioids in studies of antinociceptive tolerance and
    biological adaptations that accompany prolonged administration.
    Those interested in meeting with the speaker please contact