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  • Neuroscience Seminar Series

    Vendredi, 27 septembre 2019, 11:30, R229 (2e étage), Centre Universitaire des Saints Pères, 45 rue des Saints Pères, 75006 Paris

    Laura M. Bohn, Professor of Molecular Medicine and Neuroscience, The Scripps Research Institute in Jupiter, FL, USA Title: Harnessing opioid receptor signaling to improve therapeutic potential

    Abstract:

    When drugs bind to receptors, they coordinate a series of signaling events that lead to physiological responses. Opioid receptors are G protein-coupled receptors (GPCRs); in addition to coupling to G proteins, they can be regulated by many different cellular proteins. The interactions between receptors and their signaling partners can vary between neuronal populations and tissues throughout the body; therefore there may be an opportunity to maintain efficacy in pain pathways while avoiding other side effects associated with opioid pain management. We are developing compounds that selectively engage certain signaling pathways over others to directly test if we can improve mu opioid receptor (MOR)- mediated pain relief while avoiding certain side effects, such as opioid overdose. Studies will also be presented comparing these compounds to conventional opioids in studies of antinociceptive tolerance and biological adaptations that accompany prolonged administration. Those interested in meeting with the speaker please contact nicolas.marie@parisdescartes.fr