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    7 Juillet 2023 –  Mariano Soiza-Reilly (Institute of Physiology, Molecular Biology and Neurosciences – University of Buenos Aires – CONICET)- Synaptic refinement of afferents to raphe 5-HT neurons: Implications for psychiatric disorders

    Psychiatric disorders including depression, anxiety and stress vulnerability represent main disabling conditions for individual’s life. Recent studies suggest that many aspects of these pathologies could have an early origin during childhood. Our goal is to investigate how maladaptive neurodevelopmental mechanisms…  Continue reading

    événements, Non classé, séminaires

    12 Mai 2023 – Jean-François Perrier (Université de Copenhague, Danemark) – Understanding the cellular mechanisms responsible for neurodevelopmental encephalopathies – the example of STXBP1 encephalopathies

    De novo mutations in Stxbp1 are among the most prevalent causes of neurodevelopmental disorders, and lead to haploinsufficiency, cortical hyperexcitability, epilepsy and other symptoms. Given that Munc18-1, the protein encoded by …  Continue reading

    événements, séminaires

    3 Mars 2023 – Francesco BATTAGLIA (Radbound Université Radboud, Pays-Bas) – Hippocampal gamma oscillations mediating cortico-hippocampal oscillations and shaping hippocampal temporal code

    Theta sequences and phase precession shape hippocampal activity and are considered key underpinnings of memory formation. Theta sequences are sweeps of spikes from multiple cells, tracing trajectories from past to future. Phase precession is the correlation between theta firing phase…  Continue reading

    événements, séminaires

    10 Février 2023 – Mohamed Jaber (Université de Poitiers) – Genetic and environmental animal models of autism reproduce the spectrum of the disease

    Genetic and environmental factors increase autism spectrum disorder (ASD) incidence and this has led to the generation of corresponding animal models, with some showing strong construct and face validity. In this line, we have recently published a series of several studies on ASD environmental…  Continue reading

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    3 Février 2023 – Jenny GUNERSEY (Université de Melbourne, Australie) – Excitatory synapse regulators and their potential as therapeutic targets in chronic conditions

    In this presentation, I will describe our recent work on a family of proteins with important roles in excitatory synapse development and maintenance. These proteins have been identified as substrates of the enzyme BACE1, a potential therapeutic target in Alzheimer’s…  Continue reading

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    25 Novembre 2022 – Hélène Puccio (Institut NeuroMyoGene, Université Claude Bernard, Lyon et Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg) – Disruption of the CoQ10 biosynthetic Complex Q causes mitochondrial dysfunction and Ca2+ imbalance in Purkinje neurons in COQ8A-ataxia

    COQ8A-Ataxia is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The encoded mitochondrial protein is involved in the regulation of Coenzyme Q10 biosynthesis. Previous studies on the constitutive Coq8a-/- mice indicated specific alterations of cerebellar…  Continue reading

    événements, séminaires

    2 Décembre 2022 – Gabriel Lepousez (Unité Perception et Mémoire, Institut Pasteur) – How brain circuits sense and integrate peripheral immune signals

    Upon infection, bacterial compounds, and the pro-inflammatory cytokines they elicit, induce a complex response coordinated by the brain and known as “sickness behavior”. This response induces stereotyped behavioral changes (reduced locomotion and food intake, social avoidance), metabolic adjustments (fever, glycemia),…  Continue reading

    événements, séminaires

    9 Décembre 2022 – Jean-Michel Perrin (Institut de Biologie Paris-Seine) – Reconstructing rodent and human neuronal networks to model neurodegenerative syndromes

    Human brain is a complex organ composed of several hundred billions of cells and even more numerous interconnected cellular interactions. There is a high demand for experimental models to study these interactions in various contexts, ranging from cognitive sciences to studies…  Continue reading