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    Jeudi, 12 Mai 2022 – Melissa Bowerman (Keele University, UK) – Combining bioinformatic and drug repurposing approaches to develop second-generation therapies for spinal muscular atrophy

    Spinal muscular atrophy (SMA) is a devastating childhood disease caused by loss of function of the survival motor neuron (SMN) gene, leading to the death of nerve and muscle cells. The first SMN gene replacement therapies have recently been approved…  Continue reading

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    1 Avril 2022 – Markus Heilig (Université de Linköping, Suède) – Neurobiological mechanisms of individual vulnerability to alcohol addiction-like behaviors

    Neurobiological research on alcohol addiction had grown, but no mechanistically novel medications have been approved in more than 15 years. Promising candidates have failed in development. What have we been missing? Three themes have emerged from our attempts to address…  Continue reading

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    29 Octobre 2021 – Daniel Schulz (Neuro-PSI, Université Paris-Saclay) – Studying tactile feature encoding in the somatosensory cortex for optimizing a closed-loop brain-machine interface in mice

    Tactile information is acquired and processed in the brain through concerted interactions between movement and sensation. We study neuronal processes responsible for the coding of sensorimotor information in the barrel cortex of rodents by using a comprehensive approach including electrophysiological,…  Continue reading

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    22 Octobre 2021 – Anita Lüthi (Université de Lausanne, Suisse) – When the locus coeruleus speaks up in sleep: advancing the neurobiology of sensory vigilance

    There is no doubt that sleep is quite the opposite of wakefulness. Behaviorally, meaningful interactions with the environment are suppressed; neurobiologically, wake-promoting brain areas are silent. However, since decades we know that at least some wake-promoting areas continue to discharge action potentials…  Continue reading

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    15 Octobre 2021 – German Sumbre (ENS, Paris) – Principles of functional circuit connectivity: Insights from the zebrafish optic tectum

    Spontaneous neuronal activity in sensory brain regions is spatiotemporally structured, suggesting that this ongoing activity may have a functional role. Nevertheless, the neuronal interactions underlying these spontaneous activity patterns, and their biological relevance, remain elusive. We addressed these questions using…  Continue reading