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    7 Octobre 2022 – Fekrije Selimi  (Collège de France, Paris)- The developmental history of the molecular synaptic code controlling excitatory connectivity

    The mature brain results from the formation of precise networks between functionally and morphologically distinct types of neurons. A given neuron forms synapses with a limited number of partners and on precise subcellular localizations. Understanding what controls this specificity is…  Continue reading

    événements, séminaires

    23 Septembre 2022 – Sébastian Bouret (ICM, Paris) – Neural basis of decision-making in primates. In the lab and beyond

    The presentation will cover the cognitive and neurobiological functions underlying cost-benefits decision making in primates. After covering data from laboratory experiments, I will present recent studies aimed at understanding how these data can help understand how specific neuro-cognitive operations allow…  Continue reading

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    24 Juin 2022 – Pierre Paoletti (Institut de Biologie de l’ENS, Paris) – New lights on neurotransmission: from molecular optogenetics to excitatory glycine receptors

    The function of the human brain and its remarkable capacity for information storage and experience-dependent change hinge on the dynamics of chemical synapses – main ‘contact points’ between neurons. My team has a long-standing interest in studying the molecular principles…  Continue reading

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    Jeudi, 12 Mai 2022 – Melissa Bowerman (Keele University, UK) – Combining bioinformatic and drug repurposing approaches to develop second-generation therapies for spinal muscular atrophy

    Spinal muscular atrophy (SMA) is a devastating childhood disease caused by loss of function of the survival motor neuron (SMN) gene, leading to the death of nerve and muscle cells. The first SMN gene replacement therapies have recently been approved…  Continue reading

    événements, séminaires

    1 Avril 2022 – Markus Heilig (Université de Linköping, Suède) – Neurobiological mechanisms of individual vulnerability to alcohol addiction-like behaviors

    Neurobiological research on alcohol addiction had grown, but no mechanistically novel medications have been approved in more than 15 years. Promising candidates have failed in development. What have we been missing? Three themes have emerged from our attempts to address…  Continue reading