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    10 Février 2023 – Mohamed Jaber (Université de Poitiers) – Genetic and environmental animal models of autism reproduce the spectrum of the disease

    Genetic and environmental factors increase autism spectrum disorder (ASD) incidence and this has led to the generation of corresponding animal models, with some showing strong construct and face validity. In this line, we have recently published a series of several studies on ASD environmental…  Continue reading

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    3 Février 2023 – Jenny GUNERSEY (Université de Melbourne, Australie) – Excitatory synapse regulators and their potential as therapeutic targets in chronic conditions

    In this presentation, I will describe our recent work on a family of proteins with important roles in excitatory synapse development and maintenance. These proteins have been identified as substrates of the enzyme BACE1, a potential therapeutic target in Alzheimer’s…  Continue reading

    événements, séminaires

    25 Novembre 2022 – Hélène Puccio (Institut NeuroMyoGene, Université Claude Bernard, Lyon et Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg) – Disruption of the CoQ10 biosynthetic Complex Q causes mitochondrial dysfunction and Ca2+ imbalance in Purkinje neurons in COQ8A-ataxia

    COQ8A-Ataxia is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The encoded mitochondrial protein is involved in the regulation of Coenzyme Q10 biosynthesis. Previous studies on the constitutive Coq8a-/- mice indicated specific alterations of cerebellar…  Continue reading

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    2 Décembre 2022 – Gabriel Lepousez (Unité Perception et Mémoire, Institut Pasteur) – How brain circuits sense and integrate peripheral immune signals

    Upon infection, bacterial compounds, and the pro-inflammatory cytokines they elicit, induce a complex response coordinated by the brain and known as “sickness behavior”. This response induces stereotyped behavioral changes (reduced locomotion and food intake, social avoidance), metabolic adjustments (fever, glycemia),…  Continue reading

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    9 Décembre 2022 – Jean-Michel Perrin (Institut de Biologie Paris-Seine) – Reconstructing rodent and human neuronal networks to model neurodegenerative syndromes

    Human brain is a complex organ composed of several hundred billions of cells and even more numerous interconnected cellular interactions. There is a high demand for experimental models to study these interactions in various contexts, ranging from cognitive sciences to studies…  Continue reading

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    14 Octobre 2022 – Anne-Noël Samaha (Université de Montréal) – Addiction to cocaine: How you take the drug is more decisive than how much

    Exceptionnellement ce séminaire aura lieu en Salle des thèses (3ème étage) – Campus Saint-Germain-des-Prés, 45 rue des Saints-Pères, 75006 Paris A widely used preclinical procedure to study features of cocaine addiction involves allowing laboratory animals to take drug continuously,…  Continue reading

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    7 Octobre 2022 – Fekrije Selimi  (Collège de France, Paris)- The developmental history of the molecular synaptic code controlling excitatory connectivity

    The mature brain results from the formation of precise networks between functionally and morphologically distinct types of neurons. A given neuron forms synapses with a limited number of partners and on precise subcellular localizations. Understanding what controls this specificity is…  Continue reading

    événements, séminaires

    23 Septembre 2022 – Sébastian Bouret (ICM, Paris) – Neural basis of decision-making in primates. In the lab and beyond

    The presentation will cover the cognitive and neurobiological functions underlying cost-benefits decision making in primates. After covering data from laboratory experiments, I will present recent studies aimed at understanding how these data can help understand how specific neuro-cognitive operations allow…  Continue reading