Neuroscience Seminar Series:
David Kleinfeld, Distinguished Professor and Experimental Biophysics Endowed Chair at University of California at San Diego
‘Cortical blood flow: From vascular networks to microstrokes and vasomotion’
Video on Média2Descartes.
What is the nature of the angioarchitecture in the cortex that allows the brain to meet the energy demands of neuronal computations? I will discuss the topology and geometry of cortical angioarchitecture, the implications of this angioarchitecture to the flow and distribution of blood, and the varied resilience and susceptibility of the vascular network and underlying neurons to blockages. I will conclude with a discussion of ongoing work on the nature of long-range correlations in the fluctuations of vascular diameter. An underlying theme of these studies is the development of new optical methods concurrent with scientific exploration.