Human brain is a complex organ composed of several hundred billions of cells and even more numerous interconnected cellular interactions. There is a high demand for experimental models to study these interactions in various contexts, ranging from cognitive sciences to studies…  Continue reading →

Continuous long-term recordings (months to years) in patients with epilepsy directly show that seizures are regulated not only in a circadian manner, but also on a much slower time scale (days to weeks). They strongly suggest the existence of specific…  Continue reading →

Exceptionnellement ce séminaire aura lieu en Salle des thèses (3ème étage) – Campus Saint-Germain-des-Prés, 45 rue des Saints-Pères, 75006 Paris A widely used preclinical procedure to study features of cocaine addiction involves allowing laboratory animals to take drug continuously,…  Continue reading →

The mature brain results from the formation of precise networks between functionally and morphologically distinct types of neurons. A given neuron forms synapses with a limited number of partners and on precise subcellular localizations. Understanding what controls this specificity is…  Continue reading →

Exceptionnellement ce séminaire aura lieu en Salle des thèses (3ème étage) – Campus Saint-Germain-des-Prés, 45 rue des Saints-Pères, 75006 Paris Research in my laboratory focuses on elucidating the principles and mechanisms by which peripheral nervous system neurons regenerate, and…  Continue reading →

The presentation will cover the cognitive and neurobiological functions underlying cost-benefits decision making in primates. After covering data from laboratory experiments, I will present recent studies aimed at understanding how these data can help understand how specific neuro-cognitive operations allow…  Continue reading →

Neural stem cells generate new neurons throughout life in the mammalian hippocampus. This process, called adult neurogenesis, is critically involved in certain forms of learning and memory. In addition, failing or altered neurogenesis has been associated with a number of…  Continue reading →

The function of the human brain and its remarkable capacity for information storage and experience-dependent change hinge on the dynamics of chemical synapses – main ‘contact points’ between neurons. My team has a long-standing interest in studying the molecular principles…  Continue reading →

The environmental context is known to plays a profound role in memory. The context is a potent retrieval cue that primes the memories that belong to that context. This is highly adaptive because it prevents interference from memories that belong…  Continue reading →

Spinal muscular atrophy (SMA) is a devastating childhood disease caused by loss of function of the survival motor neuron (SMN) gene, leading to the death of nerve and muscle cells. The first SMN gene replacement therapies have recently been approved…  Continue reading →