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    September 24th, 2021 – Séverine Boillée (ICM, Paris) – Modifying macrophages at the periphery has the capacity to modify microglial reactivity and to extend ALS mouse survival

    Microglia, the macrophage of the CNS and peripheral macrophages, combined, have been implicated in Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease, but without discriminating their respective roles. Since we have shown that microglial cells participated to…  Continue reading

    events, seminars

    November 6, 2020 – Stéphane Dieudonné (ENS, Paris) – A sequential strategy for multi photon actuation and recording of membrane voltage in awake animals

    Technologies for recording and manipulating neuronal membrane potential in vivo in defined neuronal populations with high fidelity will be essential to understand how information is represented, processed, and propagated in the brain. Genetically encoded voltage indicators and optogenetic actuators are…  Continue reading

    events, seminars

    October 16, 2020 – Philippe Faure (IBPS, Paris) – Exploratory behavior, individual trait and nicotine addiction: the role of dopamine

    Consistent individual differences in behaviours represent an ubiquitous feature in animal populations. These behavioural differences among individuals define personality and have been linked to the susceptibility to addiction. Indeed, the susceptibility to develop drug addiction differs substantially between individuals and some traits that characterize an individual,…  Continue reading

    events, seminars, videos

    October 9, 2020 – Gregory Gauvain (Institut de la Vision, Paris) – Optogenetics for vision restoration: toward clinical trials

    Using vector and genetic constructs most suitable for vision restoration in patients with retinopathies, we have demonstrated temporal resolution compatible with highly dynamic visual scenes and a visual acuity above legal blindness. Captation et conception vidéo: Service audiovisuel de Paris Descartes. Video sur MédiasD   Continue reading

    events, seminars

    Seminar program 2020

    Friday at 11:30 a.m. in Conference room R229 17/01 Martin Giurfa (Research Center, University of Toulouse, France)24/01 Naguib Mechawar (Human brain bank, McGill University, Montréal, Canada)07/02 Ruben Portugues (Max Planck Institute of Neurobiology, Martinsried, Germany)25/09 Caroline Rouaux…  Continue reading

    events, seminars, videos

    September 25, 2020 – Caroline Rouaux (Inserm U1118, University of Strasbourg, France) – Evaluation of the corticofugal hypothesis in ALS

    Amyotrophic lateral sclerosis (ALS) is the third most frequent neurodegenerative disease after Alzheimer’s and Parkinson’s diseases, and the most frequent disease of the adult motoneuron. Clinically and histopathologically, ALS is defined as the simultaneous degeneration of corticospinal neurons (CSN) in…  Continue reading