seminars
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events, seminars
May 15, 2023 – Kishore Kuchibhotla (Johns Hopkins University, Baltimore, USA)- Insights and strategies during sensorimotor learning
Large-scale neural recordings provide an opportunity to better understand how the brain implements critical behavioral computations related to goal-directed learning. In this seminar, I will argue that re-visiting our understanding of the shape of the learning curve and… Continue reading
events, seminars
May 12, 2023 – Jean-François Perrier (University of Copenhagen, Denmark) – Understanding the cellular mechanisms responsible for neurodevelopmental encephalopathies – the example of STXBP1 encephalopathies
De novo mutations in Stxbp1 are among the most prevalent causes of neurodevelopmental disorders, and lead to haploinsufficiency, cortical hyperexcitability, epilepsy and other symptoms. Given that Munc18-1, the protein encoded by … Continue reading
events, seminars
March 3, 2023 – Francesco BATTAGLIA (Radbound University, The Netherlands) – Hippocampal gamma oscillations mediating cortico-hippocampal oscillations and shaping hippocampal temporal code.
Theta sequences and phase precession shape hippocampal activity and are considered key underpinnings of memory formation. Theta sequences are sweeps of spikes from multiple cells, tracing trajectories from past to future. Phase precession is the correlation between theta firing phase… Continue reading
events, seminars
February 10, 2023 – Mohamed JABER (Université de Poitiers, France) – Genetic and environmental animal models of autism reproduce the spectrum of the disease
Genetic and environmental factors increase autism spectrum disorder (ASD) incidence and this has led to the generation of corresponding animal models, with some showing strong construct and face validity.
In this line, we have recently published a series of several studies on ASD environmental… Continue reading
events, seminars
February 3, 2023 – Jenny GUNERSEY (University of Melbourne, Australia) – Excitatory synapse regulators and their potential as therapeutic targets in chronic conditions
In this presentation, I will describe our recent work on a family of proteins with important roles in excitatory synapse development and maintenance. These proteins have been identified as substrates of the enzyme BACE1, a potential therapeutic target in Alzheimer’s… Continue reading
events, seminars
Novembre 25, 2022 – Hélène Puccio (Institut NeuroMyoGene, Université Claude Bernard, Lyon and Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg) – Disruption of the CoQ10 biosynthetic Complex Q causes mitochondrial dysfunction and Ca2+ imbalance in Purkinje neurons in COQ8A-ataxia
COQ8A-Ataxia is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The encoded mitochondrial protein is involved in the regulation of Coenzyme Q10 biosynthesis. Previous studies on the constitutive Coq8a-/- mice indicated specific alterations of cerebellar… Continue reading
events, seminars
December 2, 2022 – Gabriel Lepousez (Perception and Memory Laboratory, Pasteur Institute) – How brain circuits sense and integrate peripheral immune signals
Upon infection, bacterial compounds, and the pro-inflammatory cytokines they elicit, induce a complex response coordinated by the brain and known as “sickness behavior”. This response induces stereotyped behavioral changes (reduced locomotion and food intake, social avoidance), metabolic adjustments (fever, glycemia),… Continue reading
events, seminars
9 Décembre 2022 – Jean-Michel Perrin (Institute of Biology Paris-Seine) – Reconstructing rodent and human neuronal networks to model neurodegenerative syndromes
Human brain is a complex organ composed of several hundred billions of cells and even more numerous interconnected cellular interactions. There is a high demand for experimental models to study these interactions in various contexts, ranging from cognitive sciences… Continue reading
events, seminars
October 28, 2022 – Christophe Bernard (Institute for Systems Neuroscience, Aix-Marseille University) – The timescale dynamics of epilepsies: from seconds to decades
Continuous long-term recordings (months to years) in patients with epilepsy directly show that seizures are regulated not only in a circadian manner, but also on a much slower time scale (days to weeks). They strongly suggest the existence of specific… Continue reading
events, seminars
October 14, 2022 – Anne-Noël Samaha (University of Montreal) – Addiction to cocaine: How you take the drug is more decisive than how much
Exceptionally this seminar will take place in Salle des thèses (3rd floor) – Saint-Germain-des-Prés Campus, 45 rue des Saints Pères, 75006 Paris
A widely used preclinical procedure to study features of cocaine addiction involves allowing laboratory animals to take drug… Continue reading