• en
  • fr
  • Neuroscience Seminar Series

    Vendredi, 21 juin 2019, 11:30, R229 (2e étage), Centre Universitaire des Saints Pères, 45 rue des Saints Pères, 75006 Paris

    Mark Kotter, Professor University of Cambridge, UK


    TitleInducible and deterministic forward programming

    of human pluripotent stem cells into somatic cell

    types. – The stem cell promise fulfilled?

    thumbnail of 2019 Kotter


    The discovery of human stem cells has fueled hopes and expectation of using human

    cells for drug discovery, research and cell therapy. However, during the past two decades,

    technical challenges have limited a broad adoption of human stem cells. Many conventional

    differentiation protocols are challenging, lack consistency, and are not scalable.

    Direct cell reprogramming is a novel synthetic biology paradigm that is revolutionising

    our understanding of cellular identity. An ever-increasing number of protocols mediating

    transitions between cellular states challenge traditional concepts of cell types.

    Reprogramming was thought to be restricted to and predetermined by conducive metastable

    states of cells. Our recent work challenges these preconceptions. By overcoming gene

    silencing phenomena in human pluripotent stem cells, it is possible to deterministically

    reprogram human iPSCs into different human cell types within time scales of less than a

    week. Large scale ‘omics studies provide a detailed insight into the molecular processes that

    govern these rapid and efficient cellular transitions. In conclusion, cellular reprogramming

    overcomes known bottlenecks of stem cell research and has the potential of providing

    reliable cells for research and large-scale applications.

    Those interested in meeting with the speaker please contact