November 23rd – Rainer Spanagel – Key role of loss of corticostriatal mGluR2 in the pathophysiology of addiction
Neuroscience Seminar Series
Friday, November 23rd. 2018, 11:30 am, R229 (2rd Floor), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris
Rainer Spanagel PhD Professor
Scientific Director of the Institute of Psychopharmacology
University of Heidelberg
Title: Key role of loss of corticostriatal mGluR2 in the pathophysiology of addiction
Neuroscience research produces too many false positive results for the clinical situation – why? I will discuss several issues related to power problems, data robustness and generalizability, tolerance development and placebo effects. I will then argue that DSM-based animal models are warranted and will provide a show case for alcohol addiction. I will discuss face, construct and predictive validity of a DSM-based animal model and will then show translational results in convergent support for a hyperglutamatergic state in the addicted brain. This state is most likely driven by a GluR2 deficit in corticostriatal projection neurons and I will show that by viral-mediated gene transfer and pharmacological rescue of prefrontal mGluR2 function drug craving and relapse is suppressed in addicted subjects.