Title: Assembling neural circuits : cells and synapses
Josh Sanes (Harvard University, USA)
Video of the event (restricted to Paris descartes members).
Neuroscience Seminar Series:
Friday, May 25th, 2018, 11:30 am, Salle des conférences (3rd Floor), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris
Abstract:
The retina is a leading model system for elucidating mechanisms that govern neural circuit
assembly and function. Visual information is passed from retinal photoreceptors to interneurons
to retinal ganglion cells (RGCs) and then on to the rest of the brain. Each of >40 RGC types
responds to specific visual features, depending on which of the >70 types of interneurons synapse
on it. As an example, I will focus on RGCs that respond selectively to motion in a single direction,
summarizing genetic, morphological and physiological studies that have led to identification of
some mechanisms that underlie assembly of the circuit that generates their direction-selectivity. I
will then discuss single-cell transcriptomic methods we are using to comprehensively identify cell
types and candidate recognition molecules in both rodent and primate retina.
Those interested in meeting with the speaker please contact
manuel.marin@parisdescartes.fr