Robyn S. Klein, Professor, Washington University School of Medicine, Departments of Internal Medicine, Neurobiology
Title: CNS innate immune responses to flaviviruses impair learning and memory
Memory impairment following neuroinvasive infection with West Nile virus (WNV) is associated with inflammatory-mediated loss o
f hippocampal synapses with lack of recovery. WNV-recovered mice display impaired spatial learning and persistence of phagocytic microglia witho
ut loss of hippocampal neurons or volume. Hippocampi of mice with poor spatial learning show increased expression of genes that drive synaptic remodeling by microglia, including the classical complement pathway and those that would limit adult neurogenesis, including interleukin (IL)-1, and increased markers of proinflammatory astrocytes. Adult neurogenesis and synaptogenesis are fundamental features of hippocampal restoration after injury, suggesting viruses might also impact these processes. This talk will provide an overview of flavivirus effects on neural cells with a focus on mechanisms of WNV-mediated impa
ct on adult neurogenesis and synaptic repair.
Neuroscience Seminar Series:
Friday, September 8th, 2017 , 11:30 am, Amphitheatre Giroud (3rd Floor), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris