Friday, January 13th, 2017 , 11:30 am, Salle des Conférences (R229), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris
Francesco Roselli – PhD Neurology and Anatomy departments, University of Ulm, Germany
‘Genetic and chemogenetic dissection of neuro-glio-vascular interactions in motoneuron disease’
ALS is recognized to display non-cell-autonomous pathogenetic cascades, in which motoneuron processes strongly affect, and are strongly influenced by, events taking place in astrocytes, microglia, vascular structures as well as other neurons. The mechanistic analysis of these interactions requires the precise spatio-temporal control of one or multiple components in vivo.
By applying chemogenetic and genetic strategies, we are now able to manipulate each cellular player independently, establishing causal links and exploring pathogenic cascades in space and time