Friday, May 27th. 2016 at 11:30 am,
Salle des Conférences (R229), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris
David Sulzer (Columbia University, NY, USA)
Title: Autophagy in CNS synapses
“Autophagy” is used to mean the degradation by a cell of its own components within lysosomes. Not long ago, this process was widely accepted to be absent from neurons, but recently the regulation of neuronal autophagy has been implicated in an enormous range of normal and disease mechanisms. We have identified autophagic regulation of presynaptic and postsynaptic function, including the ability to degrade synaptic vesicles and thereby regulate neurotransmitter release. The normal net pruning of cortical synapses over development is apparently due in part to neuronal autophagic pathways, and disturbances in this process may provide for convergent pathways that underlie central aspects of autism and forms of epilepsy.There is a free lunch for students and postdocs following the seminar. All are welcome and strongly encouraged to take advantage of this great opportunity.
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