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    Baljit Khakh – November 13th

    Neuroscience Seminar Series : thumbnail of Affiche2015_Khakh

    Friday, November 13th, 2015 at 11:30 am,

    Salle des Conférences (R229), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris

    Baljit Khakh, Professor, Department of Physology, David Geffen School of Medicine, UCLA

    Title: *Astrocyte dysfunction in neural circuits: focus on Huntington?s

    Brief description: We will report the detailed exploration of how early
    onset astrocyte dysfunction, without any evidence of accompanying
    astrogliosis, drives disease in mouse models of Huntington?s disease (HD).
    The cellular mechanisms involve dysfunctional homeostasis and signaling
    mediated by Kir4.1, Glt1 and Ca2+. Our data directly show that the rules
    for astrocyte engagement in a neuronal circuit are altered in a brain
    disease caused by a known molecular defect, and that fixing early onset
    astrocyte dysfunction can remedy cellular deficits. Overall, our data show
    that key aspects of altered neuronal excitability and cortico-striatal
    synapses associated with HD are secondary to dysfunctional
    astrocyte-mediated homeostasis and signaling, thereby providing details of
    a new striatal microcircuit mechanism in HD. The data show that prodromal
    changes in astrocytes represent novel therapeutic targets in brain