Neuroscience Seminar Series:
Frédéric Checler, DRCE INSERM, Directeur du Laboratoire de Biologie Cellulaire et Moléculaire du Vieillissement Cérébral Normal et Pathologique, IPMC, Valbonne
‘Common proteolytic pathways reveal interplay between cellular prion protein and Alzheimer’s disease’
Alzheimer’s disease results from the cerebral accumulation of amyloid peptides that are generated from a transmembrane protein (APP) upon cleavages by a set of proteolytic activities referred to as secretases. Unlike APP, the cellular prion is a GPI-anchored protein, which was shown to undergo proteolysis by yet unknown proteases. In this seminar, we will discuss the nature of the proteolytic events taking place on cellular prion and we will report on novel functions of its catabolites that ultimately unraveled a molecular cross-talk between prion and Alzheimer’s disease pathology.