INC Open Mind Seminar Series
Friday, September 30, 2011 at 11:00 am
Salle des Conférences (R229), Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris
Pierre Gressens, Inserm U676, Paris; Université Paris 7; PremUP, Paris and Centre for the Developing Brain, ICL, Londres. Recipient of this year’s “Roger de Spoelberch” prize
Perinatal inflammation: impact on the developing brain and long-term outcome
Clinical and experimental data strongly support the hypothesis that exposure to infection / inflammation during pregnancy or the perinatal period is deleterious for the brain. This can lead to the appearance of perinatal brain damage, which can lead to long term neurological and cognitive disabilities. In addition, some data also suggest that the perinatal exposure to inflammatory factors can alterate in a subtle manner the programs of brain development, which will however result in neurological deficits in adulthood. The relationship between this latter observation and human diseases remains to be demonstrated.