October 28, 2022 – Christophe Bernard (Institute for Systems Neuroscience, Aix-Marseille University) – The timescale dynamics of epilepsies: from seconds to decades

Continuous long-term recordings (months to years) in patients with epilepsy directly show that seizures are regulated not only in a circadian manner, but also on a much slower time scale (days to weeks). They strongly suggest the existence of specific molecular processes that influence the time of occurrence of seizures riding on universal biological circadian and multidien rhythms. I will show that cortical structures undergo dynamic reconfiguration of their molecular architecture in a daily manner in health and disease. Accounting for daily and multidien molecular rhythms is essential to our understanding of brain function and dysfunction.